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Showing posts with label the scientific benefits of experimenting with psychedelic drugs. Show all posts
Showing posts with label the scientific benefits of experimenting with psychedelic drugs. Show all posts

Tuesday, 8 April 2014

Creative Uses Of LSD When It Was Legal

Francis Crick, the Nobel Prize-winning father of modern genetics, was under the influence of LSD when he first deduced the double-helix structure of DNA nearly 50 years ago.
The abrasive and unorthodox Crick and his brilliant American co-researcher James Watson famously celebrated their eureka moment in March 1953 by running from the now legendary Cavendish Laboratory in Cambridge to the nearby Eagle pub, where they announced over pints of bitter that they had discovered the secret of life.Crick, who died ten days ago, aged 88, later told a fellow scientist that he often used small doses of LSD then an experimental drug used in psychotherapy to boost his powers of thought. He said it was LSD, not the Eagle's warm beer, that helped him to unravel the structure of DNA, the discovery that won him the Nobel Prize.Despite his Establishment image, Crick was a devotee of novelist Aldous Huxley, whose accounts of his experiments with LSD and another hallucinogen, mescaline, in the short stories The Doors Of Perception and Heaven And Hell became cult texts for the hippies of the Sixties and Seventies. In the late Sixties, Crick was a founder member of Soma, a legalise-cannabis group named after the drug in Huxley's novel Brave New World. He even put his name to a famous letter to The Times in 1967 calling for a reform in the drugs laws.It was through his membership of Soma that Crick inadvertently became the inspiration for the biggest LSD manufacturing conspiracy-the world has ever seen the multimillion-pound drug factory in a remote farmhouse in Wales that was smashed by the Operation Julie raids of the late Seventies.Crick's involvement with the gang was fleeting but crucial. The revered scientist had been invited to the Cambridge home of freewheeling American writer David Solomon a friend of hippie LSD guru Timothy Leary who had come to Britain in 1967 on a quest to discover a method for manufacturing pure THC, the active ingredient of cannabis.It was Crick's presence in Solomon's social circle that attracted a brilliant young biochemist, Richard Kemp, who soon became a convert to the attractions of both cannabis and LSD. Kemp was recruited to the THC project in 1968, but soon afterwards devised the world's first foolproof method of producing cheap, pure LSD. Solomon and Kemp went into business, manufacturing acid in a succession of rented houses before setting up their laboratory in a cottage on a hillside near Tregaron, Carmarthenshire, in 1973. It is estimated that Kemp manufactured drugs worth Pounds 2.5 million an astonishing amount in the Seventies before police stormed the building in 1977 and seized enough pure LSD and its constituent chemicals to make two million LSD 'tabs'. The arrest and conviction of Solomon, Kemp and a string of co-conspirators dominated the headlines for months. I was covering the case as a reporter at the time and it was then that I met Kemp's close friend, Garrod Harker, whose home had been raided by police but who had not been arrest ed. Harker told me that Kemp and his girlfriend Christine Bott by then in jail were hippie idealists who were completely uninterested in the money they were making.They gave away thousands to pet causes such as the Glastonbury pop festival and the drugs charity Release.'They have a philosophy,' Harker told me at the time. 'They believe industrial society will collapse when the oil runs out and that the answer is to change people's mindsets using acid. They believe LSD can help people to see that a return to a natural society based on self-sufficiency is the only way to save themselves.'Dick Kemp told me he met Francis Crick at Cambridge. Crick had told him that some Cambridge academics used LSD in tiny amounts as a thinking tool, to liberate them from preconceptions and let their genius wander freely to new ideas. Crick told him he had perceived the double-helix shape while on LSD.'It was clear that Dick Kemp was highly impressed and probably bowled over by what Crick had told him. He told me that if a man like Crick, who had gone to the heart of human existence, had used LSD, then it was worth using. Crick was certainly Dick Kemp's inspiration.' Shortly afterwards I visited Crick at his home, Golden Helix, in Cambridge.He listened with rapt, amused attention to what I told him about the role of LSD in his Nobel Prize-winning discovery. He gave no intimation of surprise. When I had finished, he said: 'Print a word of it and I'll sue.'

http://www.hallucinogens.com/lsd/francis-crick.html
 

Wednesday, 23 October 2013

The Scientific Benefits Of Experimenting With Psychedelic Drugs

Scientists should have access to illegal psychedelic drugs such as LSD and psilocybin to aid them in brain research, according to the government’s former drug adviser Professor David Nutt. He said that research into the deepest mysteries of the brain, including consciousness and mental illness, had been curtailed by the prohibition of the drugs.
“It’s extraordinary that 40 years of advances in brain imaging technology and there’s never been a study about this before. I think it’s a scandal, I think it’s outrageous the fact these studies have not been done. And they’ve not been done simply because the drugs were illegal.”“Neuroscience should be trying to understand how the brain works,” said Nutt, who is professor of neuropsychopharmacology at Imperial College London. “Psychedelics change the brain in, perhaps, the most profound way of any drug, at least in terms of understanding consciousness and connectivity. Therefore we should be doing a lot more of this research.

Speaking to the Guardian ahead of a lecture he will give at a University College London neuroscience symposium on Friday, Nutt said that a volunteer for a recent experiment pulled out of the study because he was worried that “being in a study with a so-called illegal drug could mean he couldn’t travel to some countries, such as America. To inhibit research to that extent is an outrage.”

Nutt’s views will challenge governments around the world which, largely, classify psychedelic drugs as harmful and illegal. The professor is used to being a thorn in the side of the authorities. In 2009, the UK’s then health secretary, Alan Johnson, sacked him from his post as chair of the government’s Advisory Council on the Misuse of Drugs for publicly stating that alcohol and tobacco were more harmful than LSD, ecstasy and cannabis.

Hundreds of clinical trials of psychedelic drugs such as LSD were carried out in the 1950s and 1960s, and successful treatments, including one for alcohol addiction, came out of the work. Since LSD was banned around the world, however, the number of scientific studies has dropped to virtually zero, and there have been no studies using modern imaging techniques such as magnetic resonance imaging (MRI) to look at what parts of the brain are affected by it.

Nutt recently published research, with colleagues at Cardiff University, on the effects of psilocybin – the active ingredient in magic mushrooms – on the brain. His team had assumed the drug might increase activity in certain parts of the brain, to explain the experience that users get when they eat magic mushrooms. Instead, MRI scans of 30 healthy volunteers showed that psilocybin seemed to decrease activity in the regions of the brain which link up different areas. The study was published in January in the journal Proceedings of the National Academy of Sciences.

“This is a hugely important way of perturbing the brain to understand the nature of consciousness,” said Nutt. At his lecture on Friday, he will examine whether psilocybin’s effects on the brain can be used as a model for psychosis. Some of the brain alterations seen as a result of taking psilocybin, he said, are similar to those seen in the brains of people with prodromal schizophrenia.

Psilocybin seems to suppress the actions of a brain system called the “default mode network” which is active whenever a person is, for example, reflecting about the world rather than engaged in a specific activity. The “task-positive network” is engaged when a person focuses on a specific job and it operates out of phase with the default mode network. But in schizophrenia, the networks are much more in phase and, under psilocybin, they are completely in phase.

“So, we’re thinking [psilocybin] might be an interesting model for early stages for schizophrenia, it might allow us to test new drugs,” said Nutt. “When people start to become psychotic, their ego boundaries break down, the relationship between them and the world gets disrupted and the relationship between their different inner experiences gets mixed up. Eventually they start hearing their own thoughts as someone else’s voice.

“That breakdown of connectivity in the brain is very classic in schizophrenia. If we can produce this in a laboratory in a normal volunteer, we can then look for new treatments and it is much more efficient to do that in normal volunteers than try to find young people who are starting to develop their illness and it’s ethically more acceptable too.”

Nutt and his colleagues are also studying potential uses for ecstasy, also known as MDMA. “The therapeutic value of MDMA for psychotherapy has been widely known until it was banned and has hardly been studied since. There have only been a couple of MDMA imaging studies, but none of them using cutting-edge technologies, so we’re doing that at present.”

In collaboration with Robin Carhart-Harris at Imperial College London, Nutt also wants to further his research into more psychedelic drugs such as LSD and ibogaine, a derivative of African root bark, which is used to treat addiction in Thailand and Cambodia.

Carrying out such work is usually difficult for researchers, however, because they have to make such lengthy applications for licences to use illegal drugs. And even if the research went ahead and showed benefits from the drugs, it is unlikely doctors would be allowed to prescribe them. Nutt recently called for the UK’s classification system of drugs to be rewritten to reflect more accurately their relative harms, and called for a regulated approach to making drugs such as MDMA and cannabis available for medical and research purposes.

“Regulations, which are arbitrary, actually make it virtually impossible to research these drugs,” said Nutt last month. “The effect these laws have had on research is greater than the effects that [George] Bush stopping stem cell research has had, because it’s been going on since the 1960s.”